Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma

In tumor-bearing animals, the membrane phospholipid phosphatidylserine (PS) suppresses immune responses, suggesting that PS signaling could counteract the antitumor effect of antibody-driven immune checkpoint blockade. Here, we show that treating melanoma-bearing mice with a PS-targeting antibody en...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Freimark, Bruce D., Gong, Jian, Ye, Dan, Gray, Michael J., Nguyen, Van, Yin, Shen, Hatch, Michaela M.S., Hughes, Christopher C.W., Schroit, Alan J., Hutchins, Jeff T., Brekken, Rolf A., Huang, Xianming
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821912/
https://ncbi.nlm.nih.gov/pubmed/27045021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-15-0250
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