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Design for immuno-oncology clinical trials enrolling both responders and nonresponders
A typical challenge facing the design and analysis of immuno-oncology (IO) trials is the prevalence of nonproportional hazards (NPH) patterns manifested in Kaplan-Meier curves under time-to-event endpoints. The NPH patterns would violate the proportional hazards assumption, and yet conventional desi...
Gardado en:
| Publicado en: | Stat Med |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7821346/ https://ncbi.nlm.nih.gov/pubmed/32944979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.8694 |
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