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A novel design for randomized immuno-oncology clinical trials with potentially delayed treatment effects

The semi-parametric proportional hazards model is widely adopted in randomized clinical trials with time-to-event outcomes, and the log-rank test is frequently used to detect a potential treatment effect. Immuno-oncology therapies pose unique challenges to the design of a trial as the treatment effe...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Contemp Clin Trials Commun
Hauptverfasser: He, Pei, Su, Zheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5935831/
https://ncbi.nlm.nih.gov/pubmed/29736436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.conctc.2015.08.003
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