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MS Binding Assays for Glycine Transporter 2 (GlyT2) Employing Org25543 as Reporter Ligand

This study describes the first binding assay for glycine transporter 2 (GlyT2) following the concept of MS Binding Assays. The selective GlyT2 inhibitor Org25543 was employed as a reporter ligand and it was quantified with a highly sensitive and rapid LC‐ESI‐MS/MS method. Binding of Org25543 at GlyT...

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Bibliografiske detaljer
Udgivet i:ChemMedChem
Main Authors: Ackermann, Thomas M., Allmendinger, Lars, Höfner, Georg, Wanner, Klaus T.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821181/
https://ncbi.nlm.nih.gov/pubmed/32734692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000342
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