Pharmacogenetic studies of thiopurine methyltransferase genotype‐phenotype concordance and effect of methotrexate on thiopurine metabolism

The discovery and implementation of thiopurine methyltransferase (TPMT) pharmacogenetics has been a success story and has reduced the suffering from serious adverse reactions during thiopurine treatment of childhood leukaemia and inflammatory bowel disease. This MiniReview summarizes four studies in...

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Bibliographic Details
Published in:Basic Clin Pharmacol Toxicol
Main Authors: Zimdahl Kahlin, Anna, Helander, Sara, Wennerstrand, Patricia, Vikingsson, Svante, Mårtensson, Lars‐Göran, Appell, Malin Lindqvist
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Minireviews
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7821157/
https://ncbi.nlm.nih.gov/pubmed/32865889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcpt.13483
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