Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway

Nε-lysine acetylation in the ER is an essential component of the quality control machinery. ER acetylation is ensured by a membrane transporter, AT-1/SLC33A1, which translocates cytosolic acetyl-CoA into the ER lumen, and two acetyltransferases, ATase1 and ATase2, which acetylate nascent polypeptide...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dieterich, Inca A., Cui, Yusi, Braun, Megan M., Lawton, Alexis J., Robinson, Nicklaus H., Peotter, Jennifer L., Yu, Qing, Casler, Jason C., Glick, Benjamin S., Audhya, Anjon, Denu, John M., Li, Lingjun, Puglielli, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7820588/
https://ncbi.nlm.nih.gov/pubmed/33479349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81447-6
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