PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing

Objectives: To evaluate the mycophenolic acid [MPA, the active form of mycophenolate mofetil (MMF)] pharmacokinetic parameters in relation to clinical response to identify target exposure ranges in pediatric patients with systemic lupus erythematosus (SLE). Methods: This was a retrospective study us...

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Publicat a:Front Pharmacol
Autors principals: Chen, Yewei, Sun, Li, Xu, Hong, Dong, Min, Mizuno, Tomoyuki, Vinks, Alexander A., Brunner, Hermine I., Li, Yifan, Li, Zhiping
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7819284/
https://ncbi.nlm.nih.gov/pubmed/33488386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.605060
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