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Inability of granule polarization by NK cells defines tumor resistance and can be overcome by CAR or ADCC mediated targeting
BACKGROUND: On encountering a susceptible target, natural killer (NK) cells mediate cytotoxicity through highly regulated steps of directed degranulation. Cytotoxic granules converge at the microtubule organizing center and are polarized toward the immunological synapse (IS), followed by granule exo...
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| Pubblicato in: | J Immunother Cancer |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMJ Publishing Group
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7817806/ https://ncbi.nlm.nih.gov/pubmed/33468562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001334 |
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