Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates

The tumor suppressor p53 integrates stress response pathways by selectively engaging one of several potential transcriptomes, thereby triggering cell fate decisions (e.g., cell cycle arrest, apoptosis). Foundational to this process is the binding of tetrameric p53 to 20-bp response elements (REs) in...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Farkas, Marina, Hashimoto, Hideharu, Bi, Yingtao, Davuluri, Ramana V., Resnick-Silverman, Lois, Manfredi, James J., Debler, Erik W., McMahon, Steven B.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817693/
https://ncbi.nlm.nih.gov/pubmed/33473123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20783-z
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