Unexpected Transcriptional Programs Contribute to Hippocampal Memory Deficits and Neuronal Stunting after Early-Life Adversity

Early-life adversity (ELA) is associated with lifelong memory deficits, yet the responsible mechanisms remain unclear. We impose ELA by rearing rat pups in simulated poverty, assess hippocampal memory, and probe changes in gene expression, their transcriptional regulation, and the consequent changes...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Bolton, Jessica L., Schulmann, Anton, Garcia-Curran, Megan M., Regev, Limor, Chen, Yuncai, Kamei, Noriko, Shao, Manlin, Singh-Taylor, Akanksha, Jiang, Shan, Noam, Yoav, Molet, Jenny, Mortazavi, Ali, Baram, Tallie Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817243/
https://ncbi.nlm.nih.gov/pubmed/33326786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108511
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