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Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium
Skin epithelium can accumulate a high burden of oncogenic mutations without morphological or functional consequences. To investigate the mechanism of oncogenic tolerance, we induced Hras(G12V) in single murine epidermal cells and followed them long term. We observed that Hras(G12V) promotes an early...
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| 發表在: | eLife |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications, Ltd
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7817173/ https://ncbi.nlm.nih.gov/pubmed/33393458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54618 |
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