Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy

Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated ANXA1 could promote the beneficial phenotype polarization of...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Li, Xing, Xia, Qian, Mao, Meng, Zhou, Huijuan, Zheng, Lu, Wang, Yi, Zeng, Zhen, Yan, Lulu, Zhao, Yin, Shi, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817101/
https://ncbi.nlm.nih.gov/pubmed/33523920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc5539
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