Annexin-A1 SUMOylation regulates microglial polarization after cerebral ischemia by modulating IKKα stability via selective autophagy

Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after brain ischemia, but the underlying mechanism remains poorly understood. Here, we demonstrated that ANXA1 is modified by SUMOylation, and SUMOylated ANXA1 could promote the beneficial phenotype polarization of...

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Pubblicato in:Sci Adv
Autori principali: Li, Xing, Xia, Qian, Mao, Meng, Zhou, Huijuan, Zheng, Lu, Wang, Yi, Zeng, Zhen, Yan, Lulu, Zhao, Yin, Shi, Jing
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Association for the Advancement of Science 2021
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7817101/
https://ncbi.nlm.nih.gov/pubmed/33523920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc5539
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