Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

BACKGROUND: TNBC is the most aggressive breast cancer with higher recurrence and mortality rate than other types of breast cancer. There is an urgent need for identification of therapeutic agents with unique mode of action for overcoming current challenges in TNBC treatment. METHODS: Different inhib...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Ding, Yahui, Chen, Xiaoping, Liu, Can, Ge, Weizhi, Wang, Qin, Hao, Xin, Wang, Mengmeng, Chen, Yue, Zhang, Quan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7816340/
https://ncbi.nlm.nih.gov/pubmed/33472669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-020-01016-8
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