Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

BACKGROUND: TNBC is the most aggressive breast cancer with higher recurrence and mortality rate than other types of breast cancer. There is an urgent need for identification of therapeutic agents with unique mode of action for overcoming current challenges in TNBC treatment. METHODS: Different inhib...

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Dettagli Bibliografici
Pubblicato in:J Hematol Oncol
Autori principali: Ding, Yahui, Chen, Xiaoping, Liu, Can, Ge, Weizhi, Wang, Qin, Hao, Xin, Wang, Mengmeng, Chen, Yue, Zhang, Quan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7816340/
https://ncbi.nlm.nih.gov/pubmed/33472669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-020-01016-8
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