Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats

Mitochondrial dysfunction has been widely accepted as a detrimental factor in subarachnoid hemorrhage (SAH)-induced early brain injury (EBI), which is eminently related to poor neurologic function outcome. Previous studies have revealed that enhancement of heat shock protein 22 (hsp22) under conditi...

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Publicado en:Redox Biol
Main Authors: Fan, Haiyan, Ding, Rui, Liu, Wenchao, zhang, Xin, Li, Ran, Wei, Boyang, Su, Shixing, Jin, Fa, Wei, Chengcong, He, Xuying, Li, Xifeng, Duan, Chuanzhi
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7816003/
https://ncbi.nlm.nih.gov/pubmed/33472123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.101856
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