Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids

OBJECTIVES: The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays a well-characterised role in the metabolism and activation of endogenous glucocorticoids (GCs). However, despite its potent upregulation at sites of inflammation, its role in peripheral metabolism and action of therapeut...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Fenton, Chloe, Martin, Claire, Jones, Rachel, Croft, Adam, Campos, Joana, Naylor, Amy J, Taylor, Angela E, Chimen, Myriam, Cooper, Mark, Lavery, Gareth G, Raza, Karim, Hardy, Rowan S
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815637/
https://ncbi.nlm.nih.gov/pubmed/33162397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2020-218493
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