Nuclear exclusion of YAP exacerbates podocyte apoptosis and disease progression in Adriamycin-induced focal segmental glomerulosclerosis

Focal segmental glomerulosclerosis (FSGS) is a chronic glomerular disease with poor clinical outcomes. Podocyte loss via apoptosis is one important mechanism underlying the pathogenesis of FSGS. Recently, Yes-associated-protein (YAP), a key downstream protein in the Hippo pathway, was identified as...

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發表在:Lab Invest
Main Authors: Zhuang, Qiyuan, Li, Fang, Liu, Jun, Wang, Hongyu, Tian, Yuchen, Zhang, Zhigang, Wang, Feng, Zhao, Zhonghua, Chen, Jianchun, Wu, Huijuan
格式: Artigo
語言:Inglês
出版: Nature Publishing Group US 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815513/
https://ncbi.nlm.nih.gov/pubmed/33203894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-020-00503-3
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