The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses

While antibodies to citrullinated proteins have become a diagnostic hallmark in rheumatoid arthritis (RA), we still do not understand how the autoimmune T cell response is influenced by these citrullinated proteins. To investigate the role of citrullinated antigens in HLA-DR1- and DR4-restricted T c...

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Publicat a:PLoS One
Autors principals: Becart, Stephane, Whittington, Karen B., Prislovsky, Amanda, Rao, Navin L., Rosloniec, Edward F.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7815092/
https://ncbi.nlm.nih.gov/pubmed/33465118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0245541
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