Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferrets

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and the elderly. Here we investigated the impact of male sex and age by infecting adult male, aged male, and adult female ferrets with SARS-CoV-2. Aged male ferrets had a decrease in...

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Bibliografske podrobnosti
izdano v:bioRxiv
Main Authors: Francis, Magen E., Richardson, Brian, McNeil, Mara, Rioux, Melissa, Foley, Mary K., Ge, Anni, Pechous, Roger D., Kindrachuk, Jason, Cameron, Cheryl M., Richardson, Christopher, Lew, Jocelyne, Cameron, Mark J., Gerdts, Volker, Falzarano, Darryl, Kelvin, Alyson A.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814824/
https://ncbi.nlm.nih.gov/pubmed/33469587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.12.426381
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