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Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferrets

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and the elderly. Here we investigated the impact of male sex and age by infecting adult male, aged male, and adult female ferrets with SARS-CoV-2. Aged male ferrets had a decrease in...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Francis, Magen E., Richardson, Brian, McNeil, Mara, Rioux, Melissa, Foley, Mary K., Ge, Anni, Pechous, Roger D., Kindrachuk, Jason, Cameron, Cheryl M., Richardson, Christopher, Lew, Jocelyne, Cameron, Mark J., Gerdts, Volker, Falzarano, Darryl, Kelvin, Alyson A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814824/
https://ncbi.nlm.nih.gov/pubmed/33469587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.12.426381
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