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Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferrets

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and the elderly. Here we investigated the impact of male sex and age by infecting adult male, aged male, and adult female ferrets with SARS-CoV-2. Aged male ferrets had a decrease in...

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Bibliografische gegevens
Gepubliceerd in:bioRxiv
Hoofdauteurs: Francis, Magen E., Richardson, Brian, McNeil, Mara, Rioux, Melissa, Foley, Mary K., Ge, Anni, Pechous, Roger D., Kindrachuk, Jason, Cameron, Cheryl M., Richardson, Christopher, Lew, Jocelyne, Cameron, Mark J., Gerdts, Volker, Falzarano, Darryl, Kelvin, Alyson A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory 2021
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814824/
https://ncbi.nlm.nih.gov/pubmed/33469587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.01.12.426381
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