Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats

BACKGROUND: Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of hypoxic-ischemic (HI)-induced brain injury. Activation of melanocortin-1 receptor (MC1R) has been shown to exert anti-inflammatory and neuroprotective effects in several neurological diseases. In the present...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Yu, Shufeng, Doycheva, Desislava Met, Gamdzyk, Marcin, Yang, Yijun, Lenahan, Cameron, Li, Gaigai, Li, Dujuan, Lian, Lifei, Tang, Jiping, Lu, Jun, Zhang, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814630/
https://ncbi.nlm.nih.gov/pubmed/33468172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02078-2
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados