Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats

BACKGROUND: Microglia-mediated neuroinflammation plays a crucial role in the pathogenesis of hypoxic-ischemic (HI)-induced brain injury. Activation of melanocortin-1 receptor (MC1R) has been shown to exert anti-inflammatory and neuroprotective effects in several neurological diseases. In the present...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Yu, Shufeng, Doycheva, Desislava Met, Gamdzyk, Marcin, Yang, Yijun, Lenahan, Cameron, Li, Gaigai, Li, Dujuan, Lian, Lifei, Tang, Jiping, Lu, Jun, Zhang, John H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814630/
https://ncbi.nlm.nih.gov/pubmed/33468172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02078-2
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