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Asparagine Endopeptidase (δ Secretase), an Enzyme Implicated in Alzheimer’s Disease Pathology, Is an Inhibitor of Axon Regeneration in Peripheral Nerves

Asparagine endopeptidase (AEP) is a lysosomal protease implicated in the pathology of Alzheimer’s disease (AD). It is known to cleave the axonal microtubule associated protein, Tau, and amyloid precursor protein (APP), both of which might impede axon regeneration following peripheral nerve injury (P...

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Bibliografske podrobnosti
izdano v:eNeuro
Main Authors: English, Arthur W., Liu, Xia, Mistretta, Olivia C., Ward, Patricia J., Ye, Keqiang
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814480/
https://ncbi.nlm.nih.gov/pubmed/33323399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0155-20.2020
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