Hydrogen deuterium exchange mass spectrometry identifies the dominant paratope in CD20 antigen binding to the NCD1.2 monoclonal antibody

A comparative canine–human therapeutics model is being developed in B-cell lymphoma through the generation of a hybridoma cell that produces a murine monoclonal antibody specific for canine CD20. The hybridoma cell produces two light chains, light chain-3, and light chain-7. However, the contributio...

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Detalles Bibliográficos
Publicado en:Biochem J
Main Authors: Uhrik, Lukas, Hernychova, Lenka, Muller, Petr, Kalathiya, Umesh, Lisowska, Malgorzata M., Kocikowski, Mikolaj, Parys, Maciej, Faktor, Jakub, Nekulova, Marta, Nortcliffe, Chris, Zatloukalova, Pavlina, Ruetgen, Barbara, Fahraeus, Robin, Ball, Kathryn L., Argyle, David J., Vojtesek, Borivoj, Hupp, Ted R.
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2021
Assuntos:
Cancer
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7813475/
https://ncbi.nlm.nih.gov/pubmed/33284343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200674
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