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Bioequivalence and Pharmacokinetic Profiles of Generic and Branded Obeticholic Acid in Healthy Chinese Subjects Under Fasting and Fed Conditions

OBJECTIVES: This study was conducted to evaluate the bioequivalence (BE) of a generic form of obeticholic acid (OCA) and Ocaliva(TM) under fasting and fed conditions and to determine the effects of food on the pharmacokinetic (PK) profiles of OCA in healthy Chinese subjects. METHODS: A randomized, s...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Wang, Meng-Na, Yu, Hai-Tao, Li, Ya-Qian, Zeng, Yun, Yang, Shuang, Yang, Guo-Ping, Pei, Qi, Huang, Jie
Format: Artigo
Sprog:Inglês
Udgivet: Dove 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7813459/
https://ncbi.nlm.nih.gov/pubmed/33469270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S289016
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