CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer

BACKGROUND: Most patients with high-grade serous ovarian cancer (HGSC) lack an effective response to immune checkpoint blockade, highlighting the need for more knowledge about what is required for successful treatment. As follicular cytotoxic CXCR5(+)CD8(+) T cells are maintained by reinvigoration b...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Yang, Moran, Lu, Jiaqi, Zhang, Guodong, Wang, Yiying, He, Mengdi, Xu, Qing, Xu, Congjian, Liu, Haiou
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2021
Témata:
Immunotherapy Biomarkers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7813306/
https://ncbi.nlm.nih.gov/pubmed/33452206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001136
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