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Identification of natural CRISPR systems and targets in the human microbiome

Many bacteria resist invasive DNA by incorporating sequences into CRISPR loci, which enable sequence-specific degradation. CRISPR systems have been well-studied from isolate genomes, but culture-independent metagenomics provides a new window into their diversity. We profiled CRISPR loci and cas gene...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Host Microbe
Hauptverfasser: Münch, Philipp C., Franzosa, Eric A., Stecher, Bärbel, McHardy, Alice C., Huttenhower, Curtis
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7813156/
https://ncbi.nlm.nih.gov/pubmed/33217332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2020.10.010
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