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Small molecules restore the function of mutant CLC5 associated with Dent disease
Dent disease type 1 is caused by mutations in the CLCN5 gene that encodes CLC5, a 2Cl(−)/H(+) exchanger. The CLC5 mutants that have been functionally analysed constitute three major classes based on protein expression, cellular localization and channel function. We tested two small molecules, 4‐phen...
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| Publicado no: | J Cell Mol Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7812281/ https://ncbi.nlm.nih.gov/pubmed/33200471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16091 |
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