Complement C5 activation promotes type 2 diabetic kidney disease via activating STAT3 pathway and disrupting the gut‐kidney axis

Diabetic kidney disease (DKD) is a severe DM complication. While complement C5 up‐regulation and gut dysbiosis are found in T2DM, their roles in DKD are unclear. Here, we investigated the effect of C5 on the gut microbiota during DKD development. Renal C5a/C5a receptor (C5aR) expression changes were...

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Bibliografske podrobnosti
izdano v:J Cell Mol Med
Main Authors: Li, Ling, Wei, Tiantian, Liu, Shuyun, Wang, Chengshi, Zhao, Meng, Feng, Yanhuan, Ma, Liang, Lu, Yanrong, Fu, Ping, Liu, Jingping
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812276/
https://ncbi.nlm.nih.gov/pubmed/33280239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.16157
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