Effect of Kidney Function and Dialysis on the Pharmacokinetics and Pharmacodynamics of Roxadustat, an Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor

BACKGROUND AND OBJECTIVES: Roxadustat is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor for anemia in chronic kidney disease. The pharmacokinetics, metabolic profile, and pharmacodynamics of roxadustat were investigated in subjects with different degrees of kidney function. M...

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Publicat a:Eur J Drug Metab Pharmacokinet
Autors principals: Groenendaal-van de Meent, Dorien, Kerbusch, Virginie, Kaspera, Rudiger, Barroso-Fernandez, Begona, Galletti, Piergiorgio, Klein, Gernot K., den Adel, Martin
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2020
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Original Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7811989/
https://ncbi.nlm.nih.gov/pubmed/33165773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13318-020-00658-w
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