Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

The mechanical challenge of attaching elastic tendons to stiff bones is solved by the formation of a unique transitional tissue. Here, we show that murine tendon-to-bone attachment cells are bi-fated, activating a mixture of chondrocyte and tenocyte transcriptomes, under regulation of shared regulat...

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Pubblicato in:eLife
Autori principali: Kult, Shiri, Olender, Tsviya, Osterwalder, Marco, Markman, Svetalana, Leshkowitz, Dena, Krief, Sharon, Blecher-Gonen, Ronnie, Ben-Moshe, Shani, Farack, Lydia, Keren-Shaul, Hadas, Salame, Tomer-Meir, Capellini, Terence D, Itzkovitz, Shalev, Amit, Ido, Visel, Axel, Zelzer, Elazar
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2021
Soggetti:
Developmental Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810463/
https://ncbi.nlm.nih.gov/pubmed/33448926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.55361
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