Genetic analysis of amyotrophic lateral sclerosis identifies contributing pathways and cell types

Despite the considerable progress in unraveling the genetic causes of amyotrophic lateral sclerosis (ALS), we do not fully understand the molecular mechanisms underlying the disease. We analyzed genome-wide data involving 78,500 individuals using a polygenic risk score approach to identify the biolo...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Saez-Atienzar, Sara, Bandres-Ciga, Sara, Langston, Rebekah G., Kim, Jonggeol J., Choi, Shing Wan, Reynolds, Regina H., Abramzon, Yevgeniya, Dewan, Ramita, Ahmed, Sarah, Landers, John E., Chia, Ruth, Ryten, Mina, Cookson, Mark R., Nalls, Michael A., Chiò, Adriano, Traynor, Bryan J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2021
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810371/
https://ncbi.nlm.nih.gov/pubmed/33523907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd9036
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