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Evidence for S2 flexibility by direct visualization of quantum dot–labeled myosin heads and rods within smooth muscle myosin filaments moving on actin in vitro

Myosins in muscle assemble into filaments by interactions between the C-terminal light meromyosin (LMM) subdomains of the coiled-coil rod domain. The two head domains are connected to LMM by the subfragment-2 (S2) subdomain of the rod. Our mixed kinetic model predicts that the flexibility and length...

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Foilsithe in:J Gen Physiol
Main Authors: Brizendine, Richard K., Anuganti, Murali, Cremo, Christine R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Rockefeller University Press 2021
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809879/
https://ncbi.nlm.nih.gov/pubmed/33439241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012751
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