A stress‐induced tyrosine‐tRNA depletion response mediates codon‐based translational repression and growth suppression

Eukaryotic transfer RNAs can become selectively fragmented upon various stresses, generating tRNA‐derived small RNA fragments. Such fragmentation has been reported to impact a small fraction of the tRNA pool and thus presumed to not directly impact translation. We report that oxidative stress can ra...

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Gepubliceerd in:EMBO J
Hoofdauteurs: Huh, Doowon, Passarelli, Maria C, Gao, Jenny, Dusmatova, Shahnoza N, Goin, Clara, Fish, Lisa, Pinzaru, Alexandra M, Molina, Henrik, Ren, Zhiji, McMillan, Elizabeth A, Asgharian, Hosseinali, Goodarzi, Hani, Tavazoie, Sohail F
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2020
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809793/
https://ncbi.nlm.nih.gov/pubmed/33346941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106696
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