A stress‐induced tyrosine‐tRNA depletion response mediates codon‐based translational repression and growth suppression

Eukaryotic transfer RNAs can become selectively fragmented upon various stresses, generating tRNA‐derived small RNA fragments. Such fragmentation has been reported to impact a small fraction of the tRNA pool and thus presumed to not directly impact translation. We report that oxidative stress can ra...

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Publicado en:EMBO J
Autores principales: Huh, Doowon, Passarelli, Maria C, Gao, Jenny, Dusmatova, Shahnoza N, Goin, Clara, Fish, Lisa, Pinzaru, Alexandra M, Molina, Henrik, Ren, Zhiji, McMillan, Elizabeth A, Asgharian, Hosseinali, Goodarzi, Hani, Tavazoie, Sohail F
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809793/
https://ncbi.nlm.nih.gov/pubmed/33346941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106696
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