The E3 ubiquitin ligase Peli1 regulates the metabolic actions of mTORC1 to suppress antitumor T cell responses

Metabolic fitness of T cells is crucial for immune responses against infections and tumorigenesis. Both the T cell receptor (TCR) signal and environmental cues contribute to the induction of T cell metabolic reprogramming, but the underlying mechanism is incompletely understood. Here, we identified...

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Dettagli Bibliografici
Pubblicato in:EMBO J
Autori principali: Ko, Chun‐Jung, Zhang, Lingyun, Jie, Zuliang, Zhu, Lele, Zhou, Xiaofei, Xie, Xiaoping, Gao, Tianxiao, Yang, Jin‐Young, Cheng, Xuhong, Sun, Shao‐Cong
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809702/
https://ncbi.nlm.nih.gov/pubmed/33215753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104532
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