ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis

The metabolic changes in melanoma cells that are required for tumor metastasis have not been fully elucidated. In this study, we show that the increase in glucose uptake and mitochondrial oxidative phosphorylation confers metastatic ability as a result of aryl hydrocarbon receptor nuclear translocat...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Huang, Chi-Ruei, Chang, Ting-Wei, Lee, Chung-Ta, Shen, Chih-Jie, Chang, Wen-Chang, Chen, Ben-Kuen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809415/
https://ncbi.nlm.nih.gov/pubmed/33446631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00299-3
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