ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis

The metabolic changes in melanoma cells that are required for tumor metastasis have not been fully elucidated. In this study, we show that the increase in glucose uptake and mitochondrial oxidative phosphorylation confers metastatic ability as a result of aryl hydrocarbon receptor nuclear translocat...

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Publicado en:Oncogenesis
Main Authors: Huang, Chi-Ruei, Chang, Ting-Wei, Lee, Chung-Ta, Shen, Chih-Jie, Chang, Wen-Chang, Chen, Ben-Kuen
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809415/
https://ncbi.nlm.nih.gov/pubmed/33446631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00299-3
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