The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells

Dendritic cells (DCs) promote T-cell mediated tolerance to self-antigens and induce inflammation to innocuous-antigens. This dual potential makes DCs fundamental players in inflammatory disorders. Evidence from inflammatory colitis mouse models and inflammatory bowel diseases (IBD) patients indicate...

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Pubblicato in:Sci Rep
Autori principali: Doñas, Cristian, Neira, Jocelyn, Osorio-Barrios, Francisco, Carrasco, Macarena, Fernández, Dominique, Prado, Carolina, Loyola, Alejandra, Pacheco, Rodrigo, Rosemblatt, Mario
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809056/
https://ncbi.nlm.nih.gov/pubmed/33446666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79122-3
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