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Counteracting CAR T cell dysfunction
In spite of high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, the efficacy of this approach is limited by generation of dysfunctional CAR T cells in vivo, conceivably induced by immunosuppressive tumor microenvironment (TME) and excessive antigen exposure. Ex...
Shranjeno v:
| izdano v: | Oncogene |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7808935/ https://ncbi.nlm.nih.gov/pubmed/33168929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01501-x |
| Oznake: |
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