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Application of physiologically based pharmacokinetic modeling to predict the pharmacokinetics of telavancin in obesity with renal impairment

PURPOSE: U.S. Food and Drug Administration (FDA) recommended telavancin dosing is based on total body weight (TBW) but lacks adjusted regimens for obese subjects with varying renal function. Our aim was to develop a physiologically based pharmacokinetic (PBPK) model of telavancin to design optimized...

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Detaylı Bibliyografya
Yayımlandı:Eur J Clin Pharmacol
Asıl Yazarlar: Wu, Wanhong, Ke, Meng, Ye, Lingling, Lin, Cuihong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Berlin Heidelberg 2021
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808764/
https://ncbi.nlm.nih.gov/pubmed/33447912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00228-020-03072-y
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