Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition

Twelve novel analogs of STAT3 inhibitor BP-1-102 were designed and synthesised with the aim to modify hydrophobic fragments of the molecules that are important for interaction with the STAT3 SH2 domain. The cytotoxic activity of the reference and novel compounds was evaluated using several human and...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Oleksak, Patrik, Psotka, Miroslav, Vancurova, Marketa, Sapega, Olena, Bieblova, Jana, Reinis, Milan, Rysanek, David, Mikyskova, Romana, Chalupova, Katarina, Malinak, David, Svobodova, Jana, Andrys, Rudolf, Rehulkova, Helena, Skopek, Vojtech, Ngoc Lam, Pham, Bartek, Jiri, Hodny, Zdenek, Musilek, Kamil
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808747/
https://ncbi.nlm.nih.gov/pubmed/33440995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1871336
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