Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer Disease pathogenesis

Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis of Alzheimer Disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene Chi3l1, is a widely-studied cerebrospinal fluid biomarker which increases with aging and early in AD. However, the funct...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Sci Transl Med
Hoofdauteurs: Lananna, Brian V., McKee, Celia A., King, Melvin W., Del-Aguila, Jorge, Dimitry, Julie M., Farias, Fabiana H. G., Nadarajah, Collin J., Xiong, David D., Guo, Chun, Cammack, Alex J., Elias, Jack A., Zhang, Jinsong, Cruchaga, Carlos, Musiek, Erik S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808313/
https://ncbi.nlm.nih.gov/pubmed/33328329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax3519
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items