Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer Disease pathogenesis

Regulation of glial activation and neuroinflammation are critical factors in the pathogenesis of Alzheimer Disease (AD). YKL-40, a primarily astrocytic protein encoded by the gene Chi3l1, is a widely-studied cerebrospinal fluid biomarker which increases with aging and early in AD. However, the funct...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Lananna, Brian V., McKee, Celia A., King, Melvin W., Del-Aguila, Jorge, Dimitry, Julie M., Farias, Fabiana H. G., Nadarajah, Collin J., Xiong, David D., Guo, Chun, Cammack, Alex J., Elias, Jack A., Zhang, Jinsong, Cruchaga, Carlos, Musiek, Erik S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808313/
https://ncbi.nlm.nih.gov/pubmed/33328329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aax3519
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