Improved prediction of HLA antigen presentation hotspots: Applications for immunogenicity risk assessment of therapeutic proteins

Immunogenicity risk assessment is a critical element in protein drug development. Currently, the risk assessment is most often performed using MHC‐associated peptide proteomics (MAPPs) and/or T‐cell activation assays. However, this is a highly costly procedure that encompasses limited sensitivity im...

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Detalhes bibliográficos
Publicado no:Immunology
Main Authors: Attermann, Anders Steenholdt, Barra, Carolina, Reynisson, Birkir, Schultz, Heidi Schiøler, Leurs, Ulrike, Lamberth, Kasper, Nielsen, Morten
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7808146/
https://ncbi.nlm.nih.gov/pubmed/33010039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.13274
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