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High-throughput rational design of the remdesivir binding site in the RdRp of SARS-CoV-2: implications for potential resistance
The use of remdesivir to treat COVID-19 will likely continue before clinical trials are completed. Due to the lengthening pandemic and evolving nature of the virus, predicting potential residues prone to mutation is crucial for the management of remdesivir resistance. Using a rational ligand-based i...
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| Published in: | iScience |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Elsevier
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7807151/ https://ncbi.nlm.nih.gov/pubmed/33490902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101992 |
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