Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

The rapid global emergence of SARS-CoV-2 has been the cause of significant health concern, highlighting the immediate need for antivirals. Viral RNA-dependent RNA polymerases (RdRp) play essential roles in viral RNA synthesis, and thus remains the target of choice for the prophylactic or curative tr...

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Publicat a:Antiviral Res
Autors principals: Shannon, Ashleigh, Le, Nhung Thi-Tuyet, Selisko, Barbara, Eydoux, Cecilia, Alvarez, Karine, Guillemot, Jean-Claude, Decroly, Etienne, Peersen, Olve, Ferron, Francois, Canard, Bruno
Format: Artigo
Idioma:Inglês
Publicat: Elsevier B.V. 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7151495/
https://ncbi.nlm.nih.gov/pubmed/32283108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2020.104793
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