Ceramides are necessary and sufficient for diet-induced impairment of thermogenic adipocytes

OBJECTIVE: Aging and weight gain lead to a decline in brown and beige adipocyte functionality that exacerbates obesity and insulin resistance. We sought to determine whether sphingolipids, such as ceramides, a class of lipid metabolites that accumulate in aging and overnutrition, are sufficient or n...

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Veröffentlicht in:Mol Metab
Hauptverfasser: Chaurasia, Bhagirath, Ying, Li, Talbot, Chad Lamar, Maschek, John Alan, Cox, James, Schuchman, Edward H., Hirabayashi, Yoshio, Holland, William L., Summers, Scott A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7807150/
https://ncbi.nlm.nih.gov/pubmed/33352310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2020.101145
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