Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis

Iron deposition is present in main lesion areas in the brains of patients with Parkinson’s disease (PD) and an abnormal iron content may be associated with dopaminergic neuronal cytotoxicity and degeneration in the substantia nigra of the midbrain. However, the cause of iron deposition and its role...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Main Authors: Guo, Jian-Jun, Yue, Feng, Song, Dong-Yan, Bousset, Luc, Liang, Xin, Tang, Jing, Yuan, Lin, Li, Wen, Melki, Ronald, Tang, Yong, Chan, Piu, Guo, Chuang, Li, Jia-Yi
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7807015/
https://ncbi.nlm.nih.gov/pubmed/33441545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03369-x
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